Professor Prasanna B Galhena
BDS (Perad'ya), M.Phil (Perad'ya), Ph.D (Kel'ya)
Professor
Department of Biochemistry and Clinical Chemistry
Department of Biochemistry and Clinical Chemistry
Specialization
Natural Products
Cancer Genetics
Proteomics associated with oral diseases
Clinical Biochemistry
Cancer Genetics
Proteomics associated with oral diseases
Clinical Biochemistry
Research Interests
- Cancer Genetics
- Herbal and Complimentary Medicine
- Proteomics in Oral Squamous Cell Carcinoma
Awards and fellowships
- Urine micro albumin/creatinine ratio in wistar rats given unboiled and boiled water collected from dug wells in high disease prevalent areas for CKDU in North Central Province (NCP) and water from low disease prevalent Huruluwewa area in NCP Thammitiyagodage MG, Gunatillake MM, Karunakaran R, Kumara WGSS, Galhena BP, Thabrew MI, awarded S Ramachandran Prize for the best paper in Nephrology, SLMA Annual Sessions 2015
- Presidential award for outstanding contribution for research in year 2014.
- Vice- chancellors award for outstanding research in year 2014.
- SLAAS, General Research Council award for the “Best Researcher in Medicine, Dental Sciences and Veterinary Medicine for the year 2013”.
- WHO travel grant to present paper titled “Cytotoxic activity of hot water and ethanolic extracts of a poly-herbal preparation comprised of Nigella sativa, Hemidesmus indicus, and Smilax glabra” at 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 2010, Berlin, Germany.
- Fellowship awarded by India- Sri Lanka Foundation to train on in-vitro toxicology assessments after radiation exposure at Indra Gandhi Centre for Atomic Research – 2010.
- Fellowship awarded by India- Sri Lanka Foundation to carry out collaborative research on cancer genetics at the Dept. of Human Genetics, Sri Ramachandra University, Chennai, India. – 2007.
- Paper presented on “The effect of periodontal therapy on glycosylated haemoglobin levels in patients with moderate to severe adult periodontitis” was judged as a commendable paper at The Kandy Society of Medicine, 23rd Annual Academic Conference, Volume 23, February 2001.
Publications
Publications in Peer Reviewed Journals:
Publications in Conference Proceedings (Oral and Poster Presentations):- Nirmani P Kaluarachchi, Malshani H Randunu, Munshifa Jainulabdeen,1 Arunthusha Thavarajah, Padmapani Padeniya, and Prasanna Galhena. Complex Y chromosome anomalies in an infertile male. JBRA Assist Reprod. 2020 Oct-Dec; 24(4): 510–512.
- Anti-hepatocarcinogenic ayurvedic herbal remedy reduces the extent of diethylnitrosamine - induced oxidative stress in rats. Prasanna Galhena, Ira Thabrew, Mayuri G. Tammitiyagodage and Vasanthi .A. Hanna Rachel Pharmacognosy Magazine, Vol 4, Issue 17, Jan-Mar, 2009 Page 19-27.
- A comparison of the cytotoxic potential of standardized aqueous and ethanolic extracts of a polyherbal mixture comprised of Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome). Sameera R. Samarakoon, Ira Thabrew, Prasanna B. Galhena, Dilip De Silva, Kamani H. Tennekoon Pharmacognosy Research, November 2010, Vol. 2(6); 335 – 342
- Effect of standardized decoction of Nigella sativa (seed), Hemidesmus indicus (root) and Smilax glabra (rhizome) on the expression of p53 and p21 genes in human hepatoma cells (HepG2) and liver of mice with chemically-induced hepatocarcinogenesis. Sameera R Samarakoon, Ira Thabrew, Prasanna B Galhena and Kamani H Tennekoon Tropical Journal of Pharmaceutical Research, February 2012: 11(1): 51-61.
- Modulation of apoptosis in human hepatocellular carcinoma (HepG2 cells) by a standardized herbal decoction of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes with anti- hepatocarcinogenic effects.Sameera R Samarakoon, Ira Thabrew, Prasanna B Galhena, Kamani H Tennekoon BMC Complementary and Alternative Medicine, 2012, 12:25
- Anti-inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (seeds), Hemidesmus indicus (root), and Smilax glabra (rhizome) mediates its anti-hepatocarcinogenic effects.Prasanna B Galhena, Sameera R Samarakoon, Ira M Thabrew, Mayuri G Thammitiyagodage, W. D Rathnasooriya, Kamani H Tennekoon. Evidence Based Complementary and Alternative Medicine,
- Cytotoxic and Apoptotic Effect of the Decoction of the Aerial Parts of Flueggea leucopyrus on Human Endometrial Carcinoma (AN3CA) Cells. Sameera R Samarakoon1*, Saman B Kotigala1, Ishani Gammana-Liyanage1, Ira Thabrew1, Kamani H Tennekoon1, Asitha Siriwardana2 and Prasanna B Galhena3 Tropical Journal of Pharmaceutical Research June 2014; 13 (6): 873-880
- Protective Effect of a Polyherbal Aqueous Extract Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Roots), and Smilax glabra (Rhizome) on Bleomycin Induced Cytogenetic Damage in Human Lymphocytes BioMed Research International, 2017, Bandula Prasanna Galhena1 S. S. R. Samarakoon,2Myrtle Ira Thabrew,2Solomon F. D. Paul,3 Venkatachalam Perumal,3 and Chinnadurai Mani4
- In Vitro Anticancer Effect of Gedunin on Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells. Luxmiga Tharmarajah, Sameera Ranganath Samarakoon, Meran Keshawa Ediriweera, Poorna Piyathilaka, Kamani Hemamamla Tennekoon, Kanishka Sithira Senathilake, Umapriyatharshini Rajagopalan, Prasanna Bandula Galhena, and Ira Thabrew BioMed Research International, 2017,
- Anti-hepatocarcinogenic and Anti-oxidant Effects of Mangrove Plant Scyphiphora hydrophyllacea Sameera R. Samarakoon, Chanthirika Shanmuganathan, Meran K. Ediriweera, Poorna Piyathilaka, Kamani H. Tennekoon, Ira Thabrew, Prasanna Galhena, E Dilip De Silva Pharmocognosy Magazine, 2017,
- The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms. Ramani Karunakaran1, M. Ira Thabrew2, G. Mayuri Thammitiyagodage1, B. Prasanna Galhena3and L.D.A. Menuka Arawwawala4 BMC Complementary and Alternative Medicine (2017) 17:312
- Effects of a decoction of Nigella sativa, Cryptolepis buchanani and Smilax glabra on human hepatoma HepG2 cell integrity. Galhena B. P., Thabrew M. I., Solomon F. D. Paul and Hanna Rachel V. A. 14th Congress on Alternatives to Animal Testing, 2007, University of Linz, Vienna, Austria. Alternatives to Animal Experimentation (ALTEX), 2007; 24(03), Page 196.
- Modulation of NF kappa B Activity by a Sri Lankan Herbal Remedy during Early Chemical Hepatocarcinogenesis. Prasanna B. Galhena1, M. Ira Thabrew2, Kamani Tennekoon2 and Mayuri G. Thammitiyagodage3. Drug Metabolism Reviews, 2009; 41(2), Page 35.
- Cytotoxic activity of hot water and ethanolic extracts of a poly-herbal preparation comprised of Nigella sativa, Hemidesmus indicus, and Smilax glabra. Samarakoon S., Galhena P., Thabrew M.I., and Tennekoon K. 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, 2010, Berlin, Germany.
- In-vitro cytotoxic potential of the aqueous extract of Securinega leucopyrus (wild) on human hepatoma (HepG2) cells: A preliminary study. Samarakoon S., Galhena P., Thabrew I., Tennekoon K.
- 16th Congress an Alternative Animal Testing, Sept. 2010, Linz, Austria.
- Expression of wild type p53 is induced in HepG2 cells by a Sri Lankan herbal decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome). Samarakoon S., Galhena P., Thabrew M. I., Tennekoon K. 9th Internatrional ISSX meeting, September 2010, Istanbul, Turkey.
- Sameera R. Samarakoon, M. Ira Thabrew, Prasanna B. Galhena, Kamani H. Tennekoon, E. Dilip De Silva, Standardized aqueous extract of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) induced apoptosis in human hepatocellular carcinoma (HepG2) cells via regulating Bax and Bcl-2 genes.5th International conference on Biotechnology and Development, organized by the Sri lanka Council for Agricultural Research Policy (SLCARP) - December 2010, Kandy, Sri Lanka.
- Galhena B.P., Samarakoon S.S.R., Thabrew M.I., Solomon F.D. Paul, Venkatachalam Perumal, and Chinnadurai Mani, A preliminary study to determine the chemoprotective potential of a herbal decoction Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome), International Conference on Radiation Biology, - November, 2010, Chennai, India.
- Sameera R. Samarakoon, M. Ira Thabrew, Prasanna B. Galhena, Kamani H. Tennekoon, E. Dilip De Silva, Standardized aqueous extract of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) induced apoptosis in human hepatocellular carcinoma (HepG2) cells via regulating Bax and Bcl-2 genes. International Conference on Natural Products and Biomedical Technology January 2011, organized by the University of Annamalai, Tamil Nadu, India.
- Sameera R. Samarakoon, M. Ira Thabrew, Prasanna B. Galhena, Kamani H. Tennekoon. A Standardized Decoction of Nigella sativa Seeds, Hemidesmus indicus Roots and Smilax glabra Rhizomes Induces Apoptosis In Human Hepatocellular Carcinoma (HepG2) Cells. 17th North American Regional ISSX meeting October 2011 in Atlanta, USA.
- Study of total glucose and cholesterol in the serum collected from patients with moderate to severe adult periodontitis. B. P. Galhena, S.M.P.M. Ruwanpura, W.R.Wimalasiri and A.Chandrasekera
- Proceedings of Annual Research Sessions 1999, University of Peradeniya, Sri Lanka
- The effect of periodontal therapy on glycosylated haemoglobin levels in patients with moderate to severe adult periodontitis. B. P. Galhena, M.P. Perera, T.M.R.A. Nishantha, P.S. Rajapkse The Kandy Society of Medicine, 23rd Annual Academic Conference, Volume 23, February 2001
- Glycosylated haemoglobin levels in patients with chronic periodontitis and it’s response to non surgical periodontal therapy. B. P. Galhena, M.P. Perera and A. Chandrasekera Proceedings of the annual research sessions, University of Peradeniya, Sri Lanka, Volume 6, November, 2001
- Development of a method for the detection of glycated low density lipoprotein in serum B. P. Galhena, M.I.Thabrew, P.K.S. Keerthisena, A. Chandrasekera, U. IllangasekeraProceedings of the Annual Research Symposium 2003, Faculty of Graduate Studies, University of Kelaniya, Sri Lanka
- A preliminary study of changes in serum protein profiles in response to non-surgical periodontal therapy. B. P. Galhena, M.I.Thabrew, A. Chandrasekera, M.P.Perera, B.G.Gangadara, and U.Illangasekera The Kandy Society of Medicine, 26th Annual Academic Conference, Volume 26, February 2004.
- Investigation of the antioxidant activity of a herbal decoction with anti-carcinogenic properties Galhena B. P., Thabrew M. I., Thammitiyagodage M. G. and Keerthisena O. P. K. Annual Research Session 2007, Sri Lanka Academy of Advancement of Science, Colombo, Sri Lanka.
- Galhena B. P., Thabrew M.I., Samarakoon S. R,Solomon F.D.P, Venkatachalam P, Tennekoon KH. In-vitro protective role of a poly-herbal preparation comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) against bleomycin induced cytogenetic damages in human peripheral blood lymphocytes: A preliminary study. Abstract of 4th Annual Scientific Sessions, 2011, Organized by the Institute of Biochemistry Molecular Biology & Biotechnology, University of Colombo, Sri Lanka.
- Samarakoon SR,Thabrew I, Galhena B. P., Tennekoon KH, de Silva ED, Effects of a standardized preparation of a decoction comprised of Nigella sativa (seeds), Hemidesmus indicus (roots), and Smilax glabra (rhizome) on the expression of key genes that are involved in tumour suppression, cell cycle arrest and apoptosis in human hepatoma (HepG2) cells. Abstract of 4th Annual Scientific Sessions, 2011, Organized by the Institute of Biochemistry Molecular Biology & Biotechnology, University of Colombo, Sri lanka.
Ongoing research
- Study the association of Lipoprotein glycation in diabetic macrovascular complications.
- Evaluate the potential cardiovascular risk of different Lipoprotein (a) [Lp (a)] isoforms.
- Study the systemic risk of chronic periodontitis focused on coronary heart diseases and diabetes mellitus.
- Study the use of soluble protein markers of oral and peri-oral cystic lesions in early diagnosis of cystic ameloblastomas.
- Assessment and evaluation of anti-cancer properties of endemic herbs targeting the development of novel anti-cancer drug leads.
- Assessment and evaluation of anti-diabetic effects of natural herbal extracts in terms of developing novel anti-diabetic drug leads.
- Pathophysiological study on the effect of drinking water in initiating and progressing the reported CKDU in North Central Province.
- Immune modulatory effects of Virgin Coconut oil (VCO); with perspective to its use in the long term management of chronic inflammatory diseases.
Contact Details
Department
Bio-Chemistry & Clinical Chemistry
Bio-Chemistry & Clinical Chemistry
Tel
+94 11 2961130 (Office)
+94 779542930 (Mobile)
+94 715352613(Mobile)
+94 11 2961130 (Office)
+94 779542930 (Mobile)
+94 715352613(Mobile)
Email
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