BSc (Hons) Human Biology (J’Pura), MSc (C’bo), PhD (Toledo, USA), Postdoctoral Fellow (WashU School of Medicine, USA)
Specialization
Molecular Biology, Protein Chemistry
Research Interests
- Structural biology
- Novel biomarkers and diagnostic methods
- Antibiotic resistant bacteria
- Herbal medicine
Awards and fellowships
- Award for Excellence in Student Teaching (Phase I) in the MBBS program at the Faculty of Medicine/University of Kelaniya, Sri Lanka in 2020
- Dr. C. Palasuntheram Prize for the oral presentation (Molecular characterization and laboratory detection of carbapenemase-producing Enterobacteriaceae) at the 28th Annual Scientific Sessions of the Sri Lanka College of Microbiologists, Sri Lanka in August 2019. (Criteria: The best microbiology research solely conducted locally by local scientists and presented at the College of Microbiologists, Sri Lanka).
- Award for the best poster presentation (“Cloning, expression and purification of recombinant anti-diabetic drug target PPARγ”) at the 1st Biannual Conference of College of Biochemists of Sri Lanka in October 2018.
- American Society for Biochemistry and Molecular Biology graduate/postdoctoral travel award for the ASBMB 2014 annual meeting held in San Diego, California, USA in April 2014.
- American Chemical Society-Division of Biological Chemistry travel award and the ACS Toledo section student travel grant for the 245th ACS national meeting held in New Orleans, Louisiana, USA in April 2013.
- Prof. L.M.V. Tillekeratne gold medal for the best performance in MSc Applied Organic Chemistry, University of Colombo in 2008.
- Prize for the best poster presented at the annual scientific sessions of the Sri Lanka College of Microbiologists in 2006.
Publications
Publications in Peer Reviewed Journals
- Fernando, K.K.M., Wijayasinghe, Y.S. (2021) Sirtuins as Potential Therapeutic Targets for Mitigating Neuroinflammation Associated With Alzheimer’s Disease, Front. Cell. Neurosci. 15:746631.
- Kumudunie W.G.M., Wijesooriya L.I., Wijayasinghe Y.S. (2021) Comparison of four low-cost carbapenemase detection tests and a proposal of an algorithm for early detection of carbapenemase-producing Enterobacteriaceaein resource-limited settings. PLoS ONE 16(1): e0245290.
- Wijayasinghe, Y.S., Bhansali, P., Viola, R.E., Kamal, M.A., Poddar, N.K. (2021) Natural Products: A Rich Source of Antiviral Drug Lead Candidates for the Management of COVID-19. Curr Pharm Des. 27(33), 3526-3550.
- Wariyapperuma W.A.N.M., Kannangara S., Wijayasinghe Y.S., Subramanium S., Jayawardena B. (2021) Fungal pretreatment to enhance the yield of phytochemicals and evaluation of α-amylase and α-glucosidase inhibition using Cinnamomum zeylanicum (L.) quills pressurized water extracts. Lett Appl Microbiol. 72(2):196-205.
- Kumudunie, W.G.M., Wijesooriya, W.R.P.L.I., Namalie, K.D., Sunil-Chandra, N.P., Wijayasinghe, Y.S. (2020) Epidemiology of multidrug-resistant Enterobacteriaceae in Sri Lanka: First evidence of blaKPC harboring Klebsiella pneumoniae. J Infect. Public Health 13 (9), 1330-1335
- Wariyapperuma, W.A.N.M., Kannangara, S., Wijayasinghe, Y.S, Subramanium, S., Jayawardena, B. (2020) In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts. PeerJ 8:e10070
- Wijayasinghe,Y.S., Tyagi,A., Poddar, N.K. (2017) Regulation of Cell Volume by Osmolytes, Cellular Osmolytes Chapter 9, 195 – 228.
- Zhao, M., Wijayasinghe, Y.S., Bhansali, P., Viola, R. E., Blumenthal, R. M. (2015) A surprising range of S-adenosylmethionine analogs support bacterial growth, Microbiology 161,674 – 682.
- Wijayasinghe, Y. S., Pavlovsky, A. G., Viola, R. E. (2014) Aspartoacylase catalytic deficiency as the cause of Canavan disease: A structural perspective, Biochemistry 53(30), 4970- 4978. [Protein data bank entries: 4MRI, 4MXU, 4NFR, 4TNU]
- Wijayasinghe, Y. S., Blumenthal, R. M., Viola, R. E. (2014) Producing proficient methyl donors from alternative substrates of S – Adenosylmethioninesynthetase, Biochemistry 53, 1521 – 1526.
- Zano, S., Wijayasinghe, Y. S., Malik, R., Smith, J., Viola, R. E. (2013) Relationship between enzyme properties and disease progression in Canavan disease, J Inherit Metab Dis 36, 1 – 6.
Research Grants
- 2017 – 2019 Molecular characterization of carbapenemase producing Enterobacteriaceae (CPE) in Sri Lanka; Principal Investigator; National Research Council, Sri Lanka.
- 2017 – 2019 In vitro assessment of insulin sensitization and anti-adipogenic effects of selected antidiabetic plant extracts; Co- Investigator; National Science Foundation, Sri Lanka.
- 2017 – 2020 Study of antidiabetic properties of Ceylon cinnamon; Co-investigator; National Science Foundation and Ministry of primary industries Sri Lanka research grant, Sri Lanka.
- 2016 – 2018 Production of recombinant peroxisome proliferator activated receptor gamma (Pparɣ) for anti-diabetic drug discovery research. Principal investigator; University of Kelaniya research grant.
- 2010 – 2012 Correlation between adiponectin levels and metabolic parameters in overweight women. University of Kelaniya research grant.
Contact Details
Department
Bio-Chemistry & Clinical Chemistry
Bio-Chemistry & Clinical Chemistry
Tel
+94 112961131 (Office)
+94 112961131 (Office)
Email
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