Dr C Wasanthi Subasinghe
BSc (Hon)(C'bo), Ph.D (Mich'State). Post Doctoral Fellow (John D.Dingell VA Medical Center,MI,USA)
Senior Lecturer (Grade I)
Department of Biochemistry and Clinical Chemistry
Department of Biochemistry and Clinical Chemistry
Specialization
Bio-Analytical Chemistry, Microfluidics
Research Interests
- Developing low cost, point of care diagnostic devices
- Application of PDMS based microfluidics devices in metabolic profiling.
- Nutritional disorders
- antioxidant therapies
- Medical Ethics
Awards and fellowships
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Michigan State University-Chemistry Department Salary Supplement Award
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Sri Lankan Presidential Fund- scholarship for post graduate education
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University of Colombo D.T.G. memorial gold medal for outstanding performance in Analytical Chemistry
Publications
Publications in Peer Reviewed Journals
- Shinsugi C, Gunasekara D, Gunawardena NK, Subasinghe W, Miyoshi M, Kaneko S, et al. (2019) Double burden of maternal and child malnutrition and socioeconomic status in urban Sri Lanka. PLoS ONE 14(10): e0224222.
- Karbwang, J., Koonrungsesomboon, N., Torres, C.E. et al. What information and the extent of information research participants need in informed consent forms: a multi-country survey. BMC Med Ethics 19, 79 (2018).
- Jayaram, B., Singh, A., Syed, I., Subasinghe, W., Kyathanahalli, C. N., Kowluru, A. (2011). 3Isoprenylcysteine carboxyl methyltransferase facilitates glucose-induced Rac1 activation, ROS generation and insulin secretion in pancreatic β-cells, Islets (2), 48
- Subasinghe, W., Syed, I., Kowluru A. (2011). Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: Evidence for regulation by Rac, Am J PhysiolRegulIntegr Comp 300 (1), R9
- Syed, I., Jayaram, B., Subasinghe, W., Kowluru, A. (2010). Tiam/Rac 1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of oxidative stress and loss of mitochondrial membrane potential in pancreatic β-cells, Biochemical Pharmacology 80(6)
- Meyer, J. A., Subasinghe, W., Sima, A A. F., Keltner, Z., Reid, G. E., Daleke, D., Spence, D. M. (2009). Zinc-activated C-peptide resistance to the type 2 diabetic erythrocyte is associated with hyperglycemia induced phosphatidylserine externalization and reversed by metformin, Molecular Bio Systems 5 (10) 1157
- Tolan, N. V., Genes, L., Subasinghe, W., Raththagala, M., Spence D. M. (2009). Personalized metabolic assessment of erythrocytes using microfluidic delivery to an array of luminescent wells, Analytical Chemistry 81(8), 3102
- Subasinghe, W., Spence, D. M. (2008) Simultaneous determination of cell aging and ATP release from erythrocytes and its implications in type 2 diabetes,AnalyticaChimicaActa 618(2), 227
- Carroll, J., Raththagala, M., Subasinghe, W., Baguzis, S., Oblak, T. D., Root, P., Spence, D. M. (2006) An altered oxidant defense system in red blood cells affects their ability to release nitric oxide-stimulating ATP, Molecular BioSystems 2(6/7), 305.
Professional Contributions
Positions held & holding in committees in the Faculty of Medicine & University of Kelaniya
- Secretary Ethics Review Committee, Faculty of Medicine, University of Kelaniya
Ongoing research
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Laboratory based evaluation of Alocilja Functionalized Magnetic Nanoparticles (AMN) and Dengue DNAzyme-Gold Nanoparticles (AuNP) for the early diagnosis of dengue from clinically suspected patients. - Developing a nanotechnology based biosensor for Dengue detection
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Development of dietary intervention and life style modification to improve the malnutrition among school children in Sri Lanka: A cluster randomized controlled trial
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Morbidity Patterns of the Patients presenting to Base Hospital Kiribathgoda
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Validation of AvidCor – a Bluetooth smart device which can reads ECG and pulse oximetry.
Contact Details
Department
Bio-Chemistry & Clinical Chemistry
Bio-Chemistry & Clinical Chemistry
Tel
+94 112961131 (Office)
+94 112961131 (Office)
Email
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