Dr P M Thusitha B Wickramasinghe
BSc(Hons)( C'bo), Ph.D (U of Arizona), Postdoctoral fellow (Karolinska Institute, Sweden)
Senior Lecturer (Grade I)
Head of the Department
Department of Biochemistry and Clinical Chemistry
Head of the Department
Department of Biochemistry and Clinical Chemistry
Specialization
Bioanalytical Chemistry
Research Interests
- Glucose metabolism
- Drug induced metabolic disturbances
- Aptamers
- Therapeutic drug monitoring
Awards and fellowships
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2005 and 2006 Mid-career fellowship-Department of Chemistry, University of Arizona
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2007 Imaging Fellowship-University of Arizona
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Promotion to highest level of Teaching Assistant
Publications
Published articles
- Hasantha Nayana Gunathilaka, Yashoda Wijebandara, N.W.B.A. Lahiru Udayanga, Deepika Amarasinghe , Thusitha P. Muhandiramlage “Larvicidal activity of the pericarp extract of Garcinia mangostana against dengue vector Aedes aegypti in Sri Lanka” Asian Pacific Journal of Tropical Medicine 2022 15(3):135-142
- Tilo Moede, Barbara Leibiger, Pilar Vaca Sanchez, Elisabetta Daré, Martin Köhler, Thusitha P. Muhandiramlage, Ingo B. Leibiger, and Per-Olof Berggren. “Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells” Rep 2020; 10: 20145.
- Zhen Li, Thusitha P.Muhandiramlage, John P. Keogh, Henry K.Hall Jr., Craig A.Aspinwall, ”Aptamer- functionalized porous phospholipid nanoshells for direct measurement of Hg2+ in urine” Anal. Bioanal. Chem. 2015, 407,953-60
- Thusitha P. Muhandiramlage, Zhiliang Chang, David L.Roberts, John P. Keogh, Henry Hall Jr., Craig A. Aspinwall,(2012) “ Determination of pore sizes and relative porosity in porous nanoshell architectures using dextran retention with single monomer resolution and proton permeation” Anal. Chem. 2012, 84 ,9754–9761
- Barbara Leibiger, Tilo Moede, Thusitha P. Muhandiramlage, Daniel Kaiser, Pilar Vaca Sanchez, Ingo Leibiger, Per-Olof Berggren “Glucagon regulates its own synthesis by autocrine signaling” Proc. Natl. Ac Sci. 2012,109, 20925-30
- Femina Rauf, Yiding Huang, Thusitha P. Muhandiramlage, Craig Aspinwall “Analysis of protein kinase A activity in insulin-secreting cells using a cell-penetrating protein substrate and capillary electrophoresis” Anal. Bioanal. Chem. 2010, 397, 3359-67
Selected presentations and posters
- “Optimized a HPLC protocol in measuring serum clozapine level in patients with Schizophrenia: A pilot study”; Thusitha Wickramasinghe, Prasanna Galhena, Nimal Punyasiri, Chamara Wijesinghe, Asiri Rodrigo. 18th Annual Academic Sessions of College of Psychiatrists (Kandy, Sri Lanka, December 2021)**Won the prize for best E-poster
- “A role for glucokinase in pancreatic alpha-cell stimulus-secretion coupling” T Moede, B Leibiger, P Vaca Sanchez, E Darc, M Kohler, TP Muhandiramlage, P-O Berggren, IB Leibiger; Diabetologia S122-S123 (2015/9/1)
- “Engineering pore density in stabilized porous phospholipid nanoshells for in vivo and intracellular sensing”; Thusitha P. Muhandiramlage, Zhiliang Cheng, John P. Keogh, David L.Roberts and Craig Aspinwall. Pittsburg Conference (New Orleans, LA, March 2008)
- “A cell penetrating glucose sensor for monitoring metabolic oscillations in pancreatic β-cells” ;Thusitha P. Muhandiramlage, Simone M. Langness, Craig Aspinwall. Regional Meeting of American Chemical Society (Tucson, AZ, October 2006)
- “Nanometer-sized glucose sensors utilizing glucose selective membrane transport proteins” Thusitha P. Muhandiramlage, Yiding Huang and Craig Aspinwall. Poster presented at American Chemical Society Spring National Meeting (San Diego, CA, March 2005)
- “Knowledge, attitudes, and practices about first aid given for childhood injuries among mothers of preschool children in Ragama MOH area, Sri Lanka” Wickramasinghe PMTB, Jayasena AKOM, Jayathilake JMPS, Jayathissa JTM, Jayathissa AVAP, Jayawardena MAT. Poster presented at 136th Anniversary International Medical Congress-Sri Lanka Medical Association (Colombo, July 2023)
- “Knowledge and selected practices of paid bystanders regarding patient care and personal protection in Colombo-North teaching hospital, Ragama, Sri Lanka” Perera KMN, Muhandiramlage TP, Gunawardane LADHP, Gimhan MA, Godage IGVU, Gunawardane WMMAS, Geethmali KPSP. Poster presented at 135th Anniversary International Medical Congress-Sri Lanka Medical Association (Colombo, June 2022)
- “Systematic Evolution of Ligands by Exponential Enrichment and its utility in identifying albumin binding DNA aptamers “AI Abeykoon, KMN Kumarasinghe, NV Chandrasekharan and PMTB Wickramasinghe. Poster presented at International Research Conference (IRC) General Sir John Kotelawala Defence University (Colombo, 2021)
Ongoing research
- Molecular detection of dengue infections
- Therapeutic drug monitoring of clozapine
Contact Details
Department
Bio-Chemistry & Clinical Chemistry
Bio-Chemistry & Clinical Chemistry
Tel
+94 112961131 (Office)
+94 71 2901998 (Mobile)
+94 112961131 (Office)
+94 71 2901998 (Mobile)
Email
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