Professor D S G Mettananda
MBBS(C'bo), DCH(C,bo), MD-Paediatrics(C,bo), DPhil(Oxford), FRCPCH(UK), FRCP(London), FRCP(Edin)
Cadre Chair and Professor
Department of Paediatrics
Department of Paediatrics
Specialization
General Paediatrics
Research Interests
- Thalassaemia
- Anaemia
- Paediatric Red Cell Disoders
- paediatric haemotology
Awards and Fellowships
Academic/Professional Awards
- Sir Andrew Caldecott Gold Medal for the best performance in Final MBBS – Faculty of Medicine, University of Colombo (2004)
- Joseph Nalliah Arumugam Memorial Scholarship for the Final MBBS – Faculty of Medicine, University of Colombo (2004)
- Professor K.N. Seneviratne Prize in Physiology – Faculty of Medicine, University of Colombo (2004)
- Professor Channa Wijesinghe Medal for Psychiatry – Faculty of Medicine, University of Colombo (2004)
- Sri Lanka College of Paediatrician Gold Medal for the best Performances in DCH (2007)
- Senior Hulme Scholarship awarded by Brasenose College, University of Oxford in recognition of the academic excellence (2013/14 and 2014/15)
- Selected as Young Physician Leader (YPL) for the World Health Summit 2016 by National academy of Science in Sri Lanka and Inter Academy Partnership
Research Awards
- President’s Award for scientific publications – 2011, 2015, 2016 and 2018
- Ten Outstanding Young Persons (TOYP) Award 2016 in Medical Research – Awarded by Junior Chamber International of Sri Lanka
- HKT Fernando Prize for the paper presented at Annual Sessions of the Sri Lanka Medical Association (2006)
- Professor Geoff Ebrahim Award for the Best Paper in Tropical Paediatrics in the 15th Annual Scientific Congress of the Sri Lanka College of Paediatricians (2012)
- Sir Frank Gunasekera Award for the best paper in Community Medicine at the 130th Anniversary International Medical Congress of the Sri Lanka Medical Association (2017)
- M. Wijerama Award for the best paper presented at the 131st Annual International Medical Congress of the Sri Lanka Medical Association (2018)
- E. Seneviratna Award for the paper presented at the 132nd Annual International Medical Congress of the Sri Lanka Medical Association (2019)
- Prof Sir Nicholas Attygalle Award for the paper presented at the 132nd Annual International Medical Congress of the Sri Lanka Medical Association (2019)
- Selected as one of the top ten finalist in the 2016 best journal article prize by the Commonwealth Scholarship Commission in the UK
- Vice Chancellor’s Award for the Most Outstanding Researcher in the Faculty of Medicine, University of Kelaniya – 2017 (1st Place)
- Vice Chancellor’s Award for the Most Outstanding Young / Early Career Researcher in the Faculty of Medicine, University of Kelaniya – 2017 (1st Place), 2018 (2nd Place) and 2019 (1st Place)
- Vice Chancellor’s Award for the Most Outstanding Senior Researcher in the Faculty of Medicine, University of Kelaniya – 2020 (2nd Place), 2021 (1st Place)
- Vice Chancellor’s Award for the recipient of the highest amount of external research grants in the Faculty of Medicine, University of Kelaniya – 2017 and 2018
- Vice Chancellor’s Award for The Researcher with the Highest Number of Publications in Indexed Journals in the Faculty of Medicine, University of Kelaniya – 2019
- Vice Chancellor’s Award for bringing honour to the University of Kelaniya by winning prestigious national or international awards – 2012, 2017, 2018, 2019 and 2021
- University of Kelaniya Senate honours for publishing in high impact journals – 2015, 2016, 2017, 2018, 2019, 2020 and 2021
- Ranked among the top 2% of Scientists in the World in 2020 list of outstanding researchers prepared by Elsevier BV and Stanford University, USA
Grants and Scholarships
- Commonwealth Medical Electives Bursary Award 2004/2005 by the Commonwealth Foundation in UK (2004) (Value – GBP 1000).
- ICP 2007 Japan Travel Fellowship – At the 25th International Congress of Paediatrics, Athens, Greece (2007) (Value – USD 800).
- Commonwealth Scholarship Award for DPhil degree tenable at University of Oxford, United Kingdom (2012-15) (Value – Over GBP 150000)
- WIMM Student Travel Fund Award – At Gordon Research Conference: Red Cells (2015) (Value – GBP 1000)
- Early Career Travel Fellowship – At the Tenth Cooley’s Anaemia Symposium (2015) (Value – USD 1500)
- Start-up grant through the Medical Research Council Discovery Award to the University of Oxford - project titled 'Co-inheritance of α-thalassaemia among patients with β-thalassaemia'(Value – GBP 60000)
- Global Challenges Research Fund Networking Grant awarded by the Academy of Medical Sciences, UK - project titled ‘Establishment of a collaborative network of clinicians and scientists working on novel genetic-based therapies for beta-thalassaemia'. (Value – GBP 24500)
- Investigator Driven Research Grant awarded by the National Research Council of Sri Lanka (NRC Grant 18-030) – project title ‘Foetal haemoglobin induction as a treatment for β-thalassaemia’. (Value – LKR 5,000,000)
Publications
Books
- Sachith Mettananda, Duantida Songdej, Tharindi Suriapperuma. A guide to paediatric red blood cell disorder. New York: Nova Science Publishers 2020. (ISBN: 978-1-53618-695-6; doi.org/10.52305/CJBB6142).
- Ishani Rodrigo, BJC Perera, Sachith Mettananda, Nalin Kitulwatte, Meranthi Fernando, Prasad Chathurangana. Snippets from the past: On the Silver Jubilee of the Sri Lanka College of Paediatricians. Colombo: Sri Lanka College of Paediatricians 2021. ISBN: 978-624-6042-00-4.
- Shaman Rajindrajith, Sachith Mettananda, Asiri Abeyagunawardena. Concise Textbook of Pediatrics. Colombo: Samudra Book Publications 2022. ISBN: 978-624-203-136-1.
Books chapters and section
- DSG Mettananda, DGH de Silva, YC Jayasinghe, TRW Rodrigo, A Pathmeswaran, APSD Abeysinghe. ‘A study on adolescent sexual and violent behaviour, drugs and alcohol abuse and its relationship to the past experiences’. In A Collection of Research Papers on Adolescent Sexual and Reproductive Health Faculty of Medicine-University of Kelaniya: Ragama; 91-119. ISBN 978-955-1214-23-4.
- Sachith Mettananda. ‘Iron-deficiency Anaemia (Sinhala)’. In Weda Sisu Denumai Suwabara Diviyay Faculty of Medicine-University of Kelaniya: Ragama; 51-2. ISBN 978-955-4563-80-3.
- W. Nirmani Yasara and Sachith Mettananda. ‘Genetic modifiers of b-thalassemia and their therapeutic implications’. In: Fetal Hemoglobin: The Panacea for Major b-Hemoglobinopathies. Publisher: Nova Science Publishers, New York, USA 2020; 221-262. ISBN 978-1-53617-955-2.
- Sachith Mettananda and Hashan Pathiraja. ‘Clinical management of b-thalassemia’. In: Fetal Hemoglobin: The Panacea for Major b-Hemoglobinopathies. Publisher: Nova Science Publishers, New York, USA 2020; 263-292. ISBN 978-1-53617-955-2.
- Sachith Mettananda, Visvalingam Arunath. ‘Glycerol Kinase Deficiency’. In: Genetic Syndromes: A Comprehensive Reference Guide. Publisher: Springer Nature. (in press).
Publications in peer reviewed Journals
- De Silva KSH, Mettananda DSG, Athauda Thamara. Some socio-demographic and health aspects of mothers in a Paediatric ward. Sri Lanka Journal of Child Health 2005; 34: 114-9.
- Senanayake MP, Mettananda DSG. Standards Medical Students Set for Themselves when Preparing for the Final MBBS Examination. Annals Academy of Medicine Singapore 2005; 34: 483-5.
- Mettananda DSG, Wickramasinghe VP, Kudalugoda Arachchi J, Lamabadusuriya SP, Ajanthan R, Kottahachchi D. Suitability of selection criteria as a measure of outcome of medical graduates: University of Colombo. The Ceylon Journal of Medical Sciences 2006; 49: 1-12.
- DSG Mettananda, Aswini D Fernando. A child with Morquio syndrome and mixed mitral valve disease. Ceylon Medical Journal 2008; 53: 24-5.
- Shaman Rajindrajith, Niranga Devanarayana, Sachith Mettananda, P Perera, S Jasmin, U Karunarathna, D Adhihetty, R Goonewardena. Constipation and functional fecal retention in a group of school children in a district in Sri Lanka. Sri Lanka Journal of Child Health 2009; 38: 60-4.
- Ranil Fernando, DSG Mettananda, L Kariyakarawana. Incidental occult carcinomas in total thyroidectomy for benign diseases of the thyroid. Ceylon Medical Journal 2009; 54: 4-6.
- Rajindrajith Shaman, Mettananda Sachith, Adihetti Deshan, Gunawardena Ruwan, Devanarayana Niranga Manjuri. Neonatal mortality in Sri Lanka: timing, causes and distribution. The Journal of Maternal-Fetal & Neonatal Medicine 2009; 22(9):791-6.
- Ranawaka PRD,Abayasuriya KC, Mettananda DSG, Abrew K de, Wijesuriya M. Clinical profile of type 2 diabetes mellitus in relation to the body mass index. Ceylon Journal of Medical Sciences 2010; 53: 23-35.
- Rajindrajith Shaman, Mettananda Sachith, Devanarayana Niranga Manjuri. Constipation during and after the civil war in Sri Lanka: a Paediatric Study. Journal of Tropical Paediatrics 2011; 57: 439-43.
- Devanarayana NM, Mettananda S, Liyanarachchi C, Nanayakkara N, Mendis N, Perera N, Rajindrajith S. Abdominal painpredominant functional gastrointestinal diseases in children and adolescents: prevalence, symptomatology and association with emotional stresses. Journal of Pediatric Gastroenterology and Nutrition 2011; 53: 659-65.
- Senanayake MP, Mettananda S, De Silva MVC. Pulmonary Langerhans cell histiocytosis masquerading as tuberculosis in an infant. Annals of Tropical Paediatrics: International Child Heath 2011; 31(4): 357-61.
- Manouri P Senanayake, DSG Mettananda, Sudharma Vidyathilake. Profound thrombocytopenia and generalized hyperpigmentation following pyrimethamine use. Sri Lanka Journal of Child Health 2011; 40: 134-5.
- DSG Mettananda, KSH de Silva. Psedohypoaldosteronism type 1 in an infant. Ceylon Medical Journal 2011; 56:71-2.
- J Wanigasinghe, SG Mettananda, DS Kodikara Arachchi. A case of Kleine-Levin syndrome. Ceylon Medical Journal 2011; 56:132-3.
- Perera P, Mettananda S. A Sri Lankan infant with vaccine associated acute flaccid paralysis. Ceylon Medical Journal 2012; 57: 42-3.
- Manouri P Senanayake, DSG Mettananda. Metastatic calcification: Be watchful when renal failure complicates renal tubular acidosis. Sri Lanka Journal of Child Health 2012; 41: 148.
- K Goto, B Kumarendran, S Mettananda, D Gunasekera, Y Fujii, S Kaneko. Analysis of effects of meteorological factors on dengue incidence in Sri Lanka using time series data. Plos One 2013; 8 (5), e63717.
- Wanigasinghe J, Mettananda S, De Silva K S, Gunethilake S. Multiple subcutaneous folds in oculocerebrorenal syndrome of Lowe. Ceylon Medical Journal 2013; 58(1): 37-38.
- Sachith Mettananda, Asvini D Fernando, Nimasari Ginige. Posterior reversible encephalopathy syndrome in a survivor of valproate-induced acute liver failure: a case report. Journal of Medical Case Reports 2013, 7:144.
- Priyantha Perera, Meranthi Fernando, Sachith Meththananda, Rohini Samaranayake. Pattern of physical growth during first six months of life among a cohort of babies living in Gampaha district, Sri Lanka. Health 2013 Vol.5, No.8A4, 23-28.
- Priyantha Perera, Meranthi Fernando, Sachith Meththananda, Rohini Samaranayake. Accuracy of Measuring Axillary Temperature Using Mercury in Glass Thermometers in Children under Five Years: A Cross Sectional Observational Study. Health 2014 Vol.6, 2115-20.
- Priyantha Perera, Meranthi Fernanado, Nayomi Ranathunga, Wikum Sampath, Rohini Samaranayake, Sachith Meththananda. Growth parameters of Sri Lankan children during infancy: A comparison with world health organization multicentre growth reference study. Journal of Human Growth and Development 2014; 24(1): 11-15.
- Cheng-Tao Yang, Anna French, Pollyanna Agnes Goh,Alistair Pagnamenta, Sachith Mettananda, Jenny Taylor, Sam Knight, Amit Nathwani, David J. Roberts, Suzanne M. Watt and Lee Carpenter. Human induced pluripotent stem cell derived erythroblasts can undergo definitive erythropoiesis and co‐express gamma and beta globins. British Journal of Haematology 2014; 166 (3): 435-48.
- P R D Ranawaka, C K Abeysekera, M P Gamage, O R Illangasekara, G R C Silva, D S G Mettananda, T Pathmanathan, A S Abeyagunawardena. Psychosocial outcomes of children and parents after renal transplantation. Sri Lanka Journal of Child Health 2015; 44(1): 38-44.
- Sachith Mettananda, Richard Gibbons, Douglas Higgs. α-Globin as a molecular target in the treatment of β-thalassemia. Blood 2015; 125(24): 3694-701.
- Sachith Mettananda, Richard Gibbons, Douglas Higgs. Understanding α-globin gene regulation and implications for the treatment of β-thalassemia. Annals of the New York Academy of Sciences 2016; 1368(1): 16-24.
- Randula Ranawaka, Kosala Karunaratne, DSG Mettananda. Attention-Deficit Hyperactivity Disorder in Childhood Epilepsy. Journal of Neurology, Neurological Sciences and Disorders 2(1): 004-006.
- Premathilaka LHRA, Lakmini MS, Thamal Dharshana LG, Nawaratne SB, Mettananda S, De Silva ST, Premawardhena AP. Stroke in sickle beta thalassemia - a case report highlighting pitfalls in management in a low prevalence country. Sri Lanka Journal of Medicine 2017; 26(2): 55-57.
- Sachith Mettananda, Christopher A. Fisher, Jackie A. Sloane-Stanley, Stephen Taylor, Udo Oppermann, Richard J. Gibbons, and Douglas R. Higgs. Selective silencing of a-globin by the histone demethylase inhibitor IOX1: A potentially new pathway for treatment of β-thalassemia. Haematologica 2017; 102: e80-e84.
- Sachith Mettananda, Chris A. Fisher, Deborah Hay, Mohsin Badat, Lynn Quek, Kevin Clark, Philip Hublitz, Damien Downes, Jon Kerry, Matthew Gosden, Jelena Telenius, Jackie A. Sloane-Stanley, Paula Faustino, Andreia Coelho, Jessica Doondeea, Batchimeg Usukhbayar, Paul Sopp, Jacqueline A. Sharpe, Jim R. Hughes, Paresh Vyas, Richard J. Gibbons & Douglas R. Higgs. Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia. Nature communications 2017; 8: 424.
- S Mettananda, DGH de Silva. Anaemia in children: are we using the correct prevention strategies? Ceylon Medical Journal 2017; 62: 73-76.
- Sachith Mettananda. Thalassaemia: In a quest towards an ultimate cure. Sri Lanka Journal of Child Health 2017; 46(3): 203-10.
- Sachith Mettananda, Harendra de Silva. Periodic deworming practice in Sri Lanka: Is it based on evidence, misconceptions or commercialism? Sri Lanka Journal of Child Health 2017; 46(4): 307-311.
- S Mettananda, DGH de Silva. Re: Anaemia and iron deficiency in pregnant women attending an antenatal clinic in a Teaching Hospital in Southern Sri Lanka. Ceylon Medical Journal 2017; 62: 255.
- Sachith Mettananda, K Phirarthana, Dhananja Namalie. Streptococcus bovis: a case report of an unusual aetiology of meningitis in a neonate with Down syndrome. Journal of Medical Case Reports 2018; 12: 93.
- Sachith Mettananda. Management of thalassaemia. Sri Lanka Journal of Child Health 2018; 47(2): 159-165.
- Tharindi Suriapperuma, R Peiris, Chamila Mettananda, Anuja Premawardhena, Sachith Mettananda. Body iron status of children and adolescents with transfusion dependent β-thalassaemia: Trends of serum ferritin and associations of optimal body iron control. BMC Research Notes 2018; 11: 547.
- C Jayamanne, S Sandamal, K Jayasundara, M Saravanabavananthan, Sachith Mettananda. Child presenting with acute adrenal crisis: a case of Smith-Lemli-Opitz Syndrome. Journal of Medical Case Reports 2018; 12: 217.
- Sachith Mettananda. Thalassaemia: Current research may provide a cure for it in the future. Sri Lanka Journal of Child Health 2018; 47(4): 372.
- Sachith Mettananda, Douglas Higgs. Molecular basis and genetic modifiers of thalassemia. Hematology/Oncology Clinics of North America 2018; 32 (2): 177–191.
- Sachith Mettananda, Kevin Clark, Chris A. Fisher, Jackie A. Sloane-Stanley, Richard J. Gibbons, Douglas R. Higgs. Phenotypic and molecular characterization of a serum-free miniature erythroid differentiation system suitable for high throughput screening and single cell assays. Experimental Hematology 2018; 60: 10–20.
- Chamara Jayamanne, Lakkumar Fernando, Sachith Mettananda. Chiari malformation type 1 presenting as unilateral progressive foot drop: a case report and review of literature. BMC Pediatrics 2018; 18: 34.
- Sachith Mettananda, Marius Suranjan, Roshale Fernando, Tiran Dias, Chamila Mettananda, Rexan Rodrigo, Lakshman Perera, Richard Gibbons, Anuja Premawardhena, Douglas Higgs. Anaemia among females in child-bearing age: Relative contributions, effects and interactions of α- and β-thalassaemia. PLoS One 2018; 13(11): e0206928.
- Sachith Mettananda, Hashan Pathiraja, Ravindu Peiris, Nethmi Wickramarathne, Dayananda Bandara, Udaya de Silva, Chamila Mettananda, Anuja Premawardhena. Blood transfusion therapy for β-thalassaemia major and haemoglobin E β-thalassaemia: Adequacy, trends and determinants in Sri Lanka. Pediatric Blood and Cancer 2019; 66: e27643.
- Angela Allen, Shiromi Perera, Luxman Perera, Rexan Rodrigo, Sachith Mettananda, Agnes Matope, Ishari Silva, Nizri Hameed, Christopher Fisher, Nancy Olivieri, David Weatherall, Stephen Allen, Anuja Premawardhena. A “one-stop” screening protocol for haemoglobinopathy traits and iron deficiency in Sri Lanka. Frontiers in Molecular Biosciences 2019; 6: 66.
- Anuja P Premawardhana, Rasnayaka Mudiyanse, Shamila T De Silva, Nilam Jiffry, Udaya Nelumdeniya, Udaya de Silva, Sanath P Lamabadusuriya, K Pushpakumara, Randima Dissanayaka, M Jansz, I Rifaya, Upul Navarathne, V Thirukumaran, Mahinda Arambepola, Wijesundara Dayanada Bandara, U Vaidyanatha, Devan Mendis, K Weerasekara, Nalika De Silva, DK Shantha Kumara, Sujeewa D Amarasena, KK Hemantha, MACM Refai, Ishari Silva, Nizri Hameed, F Rajiyah, Sachith Mettananda, Angela Allen, David J Weatherall, Nancy F Oliveri. A nationwide survey of hospital-based thalassaemia patients and standards of care and a preliminary assessment of the national prevention program in Sri Lanka. PLoS One 2019; 14(8): e0220852.
- Sachith Mettananda, Hashan Pathiraja, Ravindu Peiris, Dayananda Bandara, Udaya de Silva, Chamila Mettananda, Anuja Premawardhena. Health related quality of life among children with transfusion dependent β-thalassaemia major and haemoglobin E β-thalassaemia in Sri Lanka: a case control study. Health and Quality of Life Outcomes 2019; 17:137.
- Sachith Mettananda, Nirmani Yasara, Christopher A. Fisher, Stephen Taylor, Richard Gibbons, Doug Higgs. Synergistic silencing of a-globin and induction of g-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for b-thalassaemia. Scientific Reports 2019; 9:11649.
- AS Athapathu, ERS Bandara, AAHS Aruppala, KMAU Chandrapala, Sachith Mettananda. A child with Gradenigo syndrome presenting with meningism: a case report. BMC Pediatrics 2019; 19: 350.
- Anuja Premawardhena, R Fernando, S Kumarage, N Nishad, D Goonatilleke, I de Silva, Sachith Mettananda. Place for elective cholecystectomy for patients with severe thalassaemia: A retrospective case control study. BMC Research Notes 2019; 12: 245.
- G Samarasekara, Sachith Mettananda, P Punchihewa. Analysis of nutritional status and factors associated with undernutrition in children aged 6-59 months in a rural area of Sri Lanka. Sri Lanka Journal of Child Health 2019; 48: 105-110.
- K Uyangoda, P Kamalanathan, Sachith Mettananda. Familial glucocorticoid deficiency presenting with hyperpigmentation, gigantism and motor development delay: a case report. Journal of Medical Case Reports 2019; 13: 280.
- Sachith Mettananda. Devising a cure for b-thalassaemia by targeting a-globin. The Sri Lanka Journal of Haematology 2019; 11:3-6.
- Mettananda C, Ismail I, Mettananda S. Patient perspectives on barriers to participating in cardiac rehabilitation. Journal of the Ceylon College of Physicians 2020; 51: 91-95.
- Sachith Mettananda, Senani Williams. Clinical and laboratory evaluation of childhood anaemia. Sri Lanka Journal of Child Health 2020; 49(1):64-70.
- Sachith Mettananda. Improving the standards of care for children with thalassaemia in Sri Lanka. Sri Lanka Journal of Child Health 2020; 49(1):94.
- A Athapathu, V Arunath, AAHS Aruppala, TJ Hoole, K Suntharesan, Sachith Mettananda. Delayed onset sinus node dysfunction in a child victim of Russell’s viper bite. Asian Cardiovascular and Thoracic Annals 2020; 28(4): 213-215.
- Visvalingam Arunath, Arjuna Salinda Athapathu, Thabitha Jebaseeli Hoole, Heshan Aruppala, Asanka Rathnasiri, Randula Ranawaka, Sachith Mettananda. Severe disfiguring scalp and facial oedema due to Henoch-Schönlein purpura in a child. Case Reports in Pediatrics 2020; Article ID 8823611.
- Phirarthana Kamalanathan, Meranthi Fernando, Rohan Jayawardena, A Upasena, Shaman Rajindrajith, Sachith Mettananda. Spondylocostal dysplasia in a 7-year-old Sri Lankan girl causing restrictive lung disease: a case report and review of literature. Case Reports in Medicine 2020; Article ID 9241207.
- Sachith Mettananda. Recent developments in the treatment of transfusion dependent thalassaemia. Ceylon Medical Journal 2020; 65: 35-38.
- Sajani Galappaththi, Shaman Rajindrajith, Sachith Mettananda. Congenital intrahepatic portosystemic shunt presenting with muco-cutaneous bleeding. Sri Lanka Journal of Child Health 2020; 49(4): 396-398.
- Anuja P. Premawardhena, Shamila T. De Silva, M. D. Dilith C. Goonatilleke, Dileepa S. Ediriweera, Sachith Mettananda, B. K. Rexan, P. Rodrigo, Angela Allen, David J. Weatherall. Marriage patterns of Sri Lanka and prevalence of consanguinity related births in patients with thalassaemia: a cross-sectional descriptive analysis. Journal of Biosocial Science 2020; 52(4): 573-584.
- Sachith Mettananda, Hashan Pathiraja, Ravindu Peiris, Miyuru Chandradasa, Dayananda Bandara, Udaya de Silva, Chamila Mettananda, Anuja Premawardhena. Psychological morbidity among children with transfusion dependent b-thalassaemia and their parents in Sri Lanka. PLoS ONE 2020; 15(2): e0228733.
- Sachith Mettananda, Sanjaya Paranamana, Roshale Fernando, Marius Suranjan, Rexan Rodrigo, Lakshman Perera, Thakshila Vipulaguna, Prasanna Fernando, Mallika Fernando, B. K. T. P. Dayanath, Yasintha Costa, Anuja Premawardhena. Microcytic anemia in children: parallel screening for iron deficiency and thalassemia provides a useful opportunity for thalassemia prevention in low- and middle-income countries. Pediatric Hematology and Oncology 2020; 37(4):326-336.
- Nirmani Yasara, Nethmi Wickramarathne, Chamila Mettananda, Aresha Manamperi, Anuja Premawardhena, Sachith Mettananda. Efficacy and safety of oral hydroxyurea in transfusion dependent b-thalassaemia: a protocol for randomised double-blind controlled clinical trial. BMJ Open 2020; 10: e041958.
- Marques P, Caimari F, Hernández-Ramírez LC, Collier D, Iacovazzo D, Ronaldson A, Magid K, Lim CT, Stals K, Ellard S, Grossman AB, Korbonits M; FIPA Consortium (including Sachith Mettananda). Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors. Journal of Clinical Endocrinology and Metabolism 2020; 105(6): e2247-e2260.
- Visvalingam Arunath, Thabitha Hoole, Asanka Rathnasri, Oshanie Muthukumarana, Ishara Kumarasiri, Nishadi Liyanage, Yasintha Costa, Sachith Mettananda. A child with Imerslund-Gräsbeck syndrome concealed by co‐existing α-thalassaemia presenting with subacute combined degeneration of the spinal cord: a case report. BMC Pediatrics 2021; 21: 41.
- Nirmani Yasara, Anuja Premawardhena, Sachith Mettananda. A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic. Orphanet Journal of Rare Diseases 2021; 16: 114.
- Angela Allen, Shiromi Perera, Sachith Mettananda, Rexan Rodrigo, Lakshman Perera, Thamal Darshana, Fiona Moggach, Anthony Jackson- Crawford, Lesley Heirene, Christopher Fisher, Nancy Olivieri, David Rees, Anuja Premawardhena, Stephen Allen. Oxidative status in the β-thalassemia syndromes in Sri Lanka; a cross-sectional survey. Free Radical Biology & Medicine 2021; 116: 337-347.
- AS Athapathu, AAHS Aruppala, TJ Hoole, V Arunath, GBAM Rathnasiri, Sachith Mettananda. A Sri Lankan boy with Thurston syndrome: a rare orofaciodigital syndrome. Sri Lanka Journal of Child Health 2021; 50(2): 356-358
- Sachith Mettananda. Screening of children with anaemia for iron deficiency and thalassemia trait provides an opportunity for thalassemia prevention in Sri Lanka. Sri Lanka Journal of Child Health 2021; 50(2): 369
- TJ Hoole, A Visvalingam, MHAD de Silva, OGW Muthukumarana, IM Kumarasiri, GBAM Rathnasiri, G Mahendra, A Premawardhena, Sachith Mettananda. Acute on chronic osteomyelitis due to coliforms in a Sri Lankan child with homozygous sickle cell disease. Sri Lanka Journal of Child Health 2021; 50(3): 558-60.
- Udara Sandakelum, Ruwan Samararathna, Hashan Pathiraja, Linushika de Silva, Reha Balasubramaniam, Gayathree de Abrew, Deshan Adihetty, Meranthi Fernando, Shobhavi Randeny, Sachith Mettananda. Multisystem inflammatory syndrome in children: A Sri Lankan case series. Sri Lanka Journal of Child Health, 2021; 50(3): 510-3.
- Sachith Mettananda. Genetic and Epigenetic Therapies for β-Thalassaemia by Altering the Expression of α-Globin Gene. Frontiers of Genome Editing 26. https://doi.org/10.3389/fgeed.2021.752278.
- Asanka Rathnasri, Udara Senarathne, Visvalingam Arunath, Thabitha Hoole, Ishara Kumarasiri, Oshanie Muthukumarana, Eresha Jasinge, Sachith Mettananda. A rare co-occurrence of Duchenne muscular dystrophy, congenital adrenal hypoplasia and glycerol kinase deficiency due to Xp21 contiguous gene deletion syndrome: case report. BMC Endocrine Disorders 2021; 21(1):214.
- Vikita Mehta, Abirami Kirubarajan, Amir Sabouhanian, Sanasi M. Jayawardena, Priya Chandrakumaran, Nila Thangavelu, Refai Cader, Sachith Mettananda, Dayananda Bandara, Shawn Khan, David J. Weatherall, Angela Allen, Anuja P. Premawardhena, Nancy Olivieri. Leg Ulcers: A Report in Patients with Hemoglobin E Beta Thalassemia and Review of the Literature in Severe Beta Thalassemia. Acta Hematologica 2021; (in press).
- Sachith Mettananda, Hashan Pathiraja, Ravindu Peiris, Dayananda Bandara, Udaya de Silva, Chamila Mettananda, Anuja Premawardhena. Maternal knowledge on curative therapies and its impact on medical care and psychological health among children with thalassaemia in Sri Lanka. Sri Lanka Journal of Child Health 2022; 51(1): 84-91.
- Anuja P Premawardhena, Dileepa Ediriweera, Amir Sabouhanian, Angela Allen, David Rees, Shanthimala de Silva, Windsor Perera, Nimal Katugaha, Mahinda Arambepola, Robert Yamashita, Sachith Mettananda, M Nilam, Vikita Mehta, M Rafai, Dayananda Bandara, Timothy St Pierre, Giulia Muraca, Christopher Fisher, Abirami Kirubarajan, Shawn Khan, Stephen Allen, Sanath P Lamabadusuriya, David J. Weatherall, Nancy F. Olivieri. Survival and complications in patients with haemoglobin E thalassaemia in Sri Lanka: a prospective, longitudinal cohort study. Lancet Global Health 2022; 10(1): e134- 141. https://doi.org/10.1016/S2214-109X(21)00446-0
- Benny Kai Guo Loo, Anthony David Okely, Aman Pulungan, Muhammad Yazid Jalaludin, Asia-Pacific 24-Hour Activity Guidelines for Children and Adolescents Committee (including Sachith Mettananda). Asia-Pacific Consensus Statement on integrated 24-hour activity guidelines for children and adolescents. British Journal of Sports Medicine 2021; Published Online First: 08 November 2021. doi: 10.1136/bjsports-2021-104527.
- Nirmani Yasara, Nethmi Wickramarathne, Chamila Mettananda, Ishari Silva, Nizri Hameed, Kumari Attanayaka, Rexan Rodrigo, Nirmani Wickramasinghe, Lakshman Perera, Aresha Manamperi, Anuja Premawardhena, Sachith Mettananda. A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent b-thalassaemia. Scientific Reports 2022; 12: 2752. org/10.1038/s41598-022-06774-8.
- Ishara Kumarasiri, Ruwan Samararathna, Udara Sandakelum, Oshani Muthukumarana, Reha Balasubramaniam, Sachith Mettananda. Acute disseminated encephalomyelitis presenting as bilateral ptosis in a Sri Lankan child. Case Reports in Pediatrics 2022; Article ID 5492155. doi.org/10.1155/2022/5492155.
- Udara Sandakelum, Ruwan Samararathna, Ishara Kumarasiri, Reha Balasubramaniam, Sachith Mettananda. Cross-fused right-to-left renal ectopia presenting as hypertension in a three-year-old. Sri Lanka Journal of Child Health 2022; (in press).
- Sachith Mettananda. Hydroxyurea reduces the blood transfusion burden in patients with thalassaemia. Sri Lanka Journal of Child Health 2022; (in press).
Professional Contributions
National Level Positions
- Secretary – Board of Study in Paediatrics, Postgraduate Institute of Medicine, University of Colombo (2021- to date)
- Founder Secretary of the Rare Disease Forum of the Sri Lanka College of Paediatricians (2017/18 and 2018/19)
- Council Member – Sri Lanka College of Paediatricians (2016/17, 2017/18 and 2021/22)
- Member of National Health Research Council of Sri Lanka (2017- to date)
- Member of National Thalassaemia Council of Sri Lanka (2016- to date)
- Member of the National Thalassaemia Screening Programme (2017-to date)
- Member – National guideline committee on deworming of children and Pregnant mothers in community setting, Ministry of Health (2017)
- Member – Subcommittee on Updating the Daft National Policy on Human Genetic Material and Data for Sri Lanka, Ministry of Health (2019)
- Member of the Formulary Revision Sub-committee for drugs related to Nutrition and Blood, Ministry of Health (2021)
- Member – National guideline committee on management of newborns suspected or confirmed to have COVID-19, Ministry of Health (2022)
Editorial Board Member
- Associate Editor – BMC Pediatrics (Nov 2020- to date)
- Editorial Board Member – Ceylon Medical Journal (Aug 2019-to date)
- Editorial Board Member – Sri Lanka Journal of Child Health (Nov 2018-to date)
Medical Faculty Responsibilities
- Clinical Co-ordinator – Faculty of Medicine, University of Kelaniya (2019 - to date)
- Chairman, Research Management Committee – Faculty of Medicine, University of Kelaniya (2022-todate)
- Academic Advisor on Career Guidance – Faculty of Medicine, University of Kelaniya. (2015-2020)
- Research Coordinator – Faculty of Medicine, University of Kelaniya (2019-2022)
- Member of the Research Management Committee – Faculty of Medicine, University of Kelaniya (2018-2022)
- Member of the Ethics Committee – Faculty of Medicine, University of Kelaniya (2019 Aug- to date)
- Coordinator of the MCQ Bank – Faculty of Medicine, University of Kelaniya. (June 2018 – Jan 2020)
- Co-chairperson – 30th Anniversary Academic Sessions of the Faculty of Medicine, University of Kelaniya (2021)