Dr N H Manamperi
MBBS (Kelaniya), PG Diploma in Medical Microbiology (Colombo), PhD (Colombo)
Senior Lecturer (Grade II)
Department of Parasitology
Department of Parasitology
Specialization
Medical Parasitology
Research Interests
- Leishmaniasis
Awards and Fellowships
Academic honors :
- Second MBBS examination (2002) – First Class honors with Distinction in Biochemistry
- Third MBBS examination (2005) – Second Class (Upper division) with Distinction in Parasitology
- Final MBBS examination (2006) – Second Class (Lower division)
- Training fellowship, Overseas Special Training Program (OSTP), National Science Foundation (NSF), Sri Lanka, 2017
Orations/Guest lectures/Invited Speech/Plenary:
- Sri Lanka College of Microbiologists CME lecture- July 2019 on ‘Challenges in the laboratory diagnosis of leishmaniasis in Sri Lanka’.
Publications
Publications in Journals:
- Karunaweera ND, Senanayake S, Ginige S, Silva H, Manamperi N, Samaranayake N, et al. (2021) Spatiotemporal distribution of cutaneous leishmaniasis in Sri Lanka and future case burden estimates. PLoS Negl Trop Dis 15(4): e0009346. https://doi.org/10.1371/journal.pntd.0009346
- Karunaweera ND, Ginige S, Senanayake S, Silva H, Manamperi N, Samaranayake N, et al. Spatial Epidemiologic Trends and Hotspots of Leishmaniasis, Sri Lanka, 2001–2018. Emerg Infect Dis. 2020;26(1):1-10. https://dx.doi.org/10.3201/eid2601.190971
- Gunathilaka, N., Semege, S., Pathirana, N., Manamperi, N., Udayanga, L., Wijesinghe, H., Premaratne, P., & Fernando, D. (2020). Prevalence of cutaneous leishmaniasis infection and clinico-epidemiological patterns among military personnel in Mullaitivu and Kilinochchi districts of the Northern Province, early war-torn areas in Sri Lanka. Parasites & vectors, 13(1), 263. https://doi.org/10.1186/s13071-020-04137-8
- Wijesinghe, H., Gunathilaka, N., Semege, S., Pathirana, N., Manamperi, N., de Silva, C., & Fernando, D. (2020). Histopathology of Cutaneous Leishmaniasis Caused by Leishmania donovani in Sri Lanka. BioMed research international, 2020, 4926819. https://doi.org/10.1155/2020/4926819
- Manamperi NH, de Silva MVC, Pathirana KPN, Abeyewickreme W, Karunaweera ND. Tissue impression smears as a supplementary diagnostic method for histopathology in cutaneous leishmaniasis in Sri Lanka. American Journal of Tropical Medicine and Hygiene, 98(3), pp.759-762. Available at: https://doi.org/10.4269/ajtmh.17-0748
- Manamperi, N.H. et al., 2017. In situ immunopathological changes in cutaneous leishmaniasis due to Leishmania donovani. Parasite Immunology, 39(3), p.e12413. Available at: http://doi.wiley.com/10.1111/pim.12413.
Publications in Conference Proceedings (Oral and Poster Presentations)
- Manamperi NH, Oghumu S, Pathiraja L, Sumanasena B, Abeyewickreme W, Satoskar AR, Karunaweera ND (2018). Evidence for association of the integrated endoplasmic reticulum stress response with L. donovani -induced cutaneous leishmaniasis in Sri Lanka. Proceedings of the 67th Annual Meeting of the American Society of Tropical Medicine and Hygiene, New Orleans, Louisiana, USA. Vol. 99 (suppl 4): p 176 (Poster).
- Manamperi Nuwani, Oghumu Steve, Pathirana Nishantha, de Silva Vipula Chandu, Pathiraja Lakmali, Sumanasena Buthsiri, Abeyewickreme Wimaladharma, Satoskar Abhay, Karunaweera Nadira (2018). Cellular immune response to cutaneous leishmaniasis in Sri Lanka: Evidence from gene expression and proteomic studies. Proceedings of the 14th International Congress of Parasitology, Daegu, Korea. Abstract No. NP-0490 (Poster).
- Manamperi NH, Oghumu S, Pathirana KPN, de Silva MVC, Abeyewickreme W, Satoskar AR, Karunaweera ND (2018). In situ immune response to cutaneous leishmaniasis in Sri Lanka. Proceedings of the ICGEB-NASSL South Asian Biotechnology Conference 2018 Colombo, Sri Lanka. p.79 (Oral).
- Manamperi NH, de Silva MVC, Pathirana KPN, Abeyewickreme W, Karunaweera ND (2017). Tissue impression smear as a supplementary diagnostic test for histopathology in cutaneous leishmaniasis. Proceedings of the 66th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Baltimore, Maryland, USA. Vol. 97 (5): Abstract No. 1229. (Poster).
- Manamperi NH, Oghumu S, Pathirana KPN, de Silva MVC, Abeyewickreme W, Satoskar AR, Karunaweera ND (2017). Prominent T helper (Th)-1 response to Leishmania donovani-induced cutaneous leishmaniasis in Sri Lanka. The Bulletin of the Sri Lanka College of Microbiologists. Vol. 15 (1): p 11 (Oral).
- Manamperi NH, Oghumu S, Pathirana KPN, de Silva MVC, Abeyewickreme W, Satoskar AR, Karunaweera ND (2017). In situ cytokine expression in cutaneous leishmaniasis due to Leishmania donovani: role of patient gender. Proceedings of the 6th World Congress on Leishmaniasis, Toledo, Spain. p 991(Poster).
- Nuwani H. Manamperi, Steve Oghumu, Nishantha Pathirana, Deepani Munidasa, Vijani Somaratne, Vipula C. de Silva, Arunasalam Pathmeswaran, Wimaladharma Abeyewickreme, Abhay R. Satoskar, Nadira D. Karunaweera 2016. Cutaneous leishmaniasis due to Leishmania donovani: role of IL-4 and IFN-gamma in lesion healing. Proceedings of the 65th Annual Meeting of the American Society of Tropical Medicine and Hygiene, Atlanta, Georgia, USA. Vol. 95 (5): Abstract No. 1759. (Poster).
- Manamperi NH, Oghumu S, Pathirana KPN, Munidasa UADD, Somaratne KKVN, de Silva M VC, Fernando CS, Pathmeswaran A, Abeyewickreme W, Satoskar AR, Karunaweera ND 2016. Role of pro-inflammatory cytokines in the pathogenesis of L. donovani-induced cutaneous leishmaniasis. Proceeding of the University of Colombo Annual Research Symposium, Colombo, Sri Lanka. p 236 (Poster)
- Nuwani Manamperi, Chandu de Silva, Nishantha Pathirana, Deepani Munidasa, Vijani Somaratne, Dileepa Ediriweera, Thilini Saparamadu, Wimaladharma Abeyewickreme, Nadira Karunaweera 2016. Granuloma formation in cutaneous leishmaniasis due to Leishmania donovani: role of patient gender. Proceedings of the International Congress for Tropical Medicine and Malaria 2016, Brisbane, Australia. Abstract No. 356 (Poster).
- Manamperi NH, Oghumu S, Pathirana KPN, Munidasa UADD, Somaratne KKVN, Rathnayake RMDI, Thilakaratne SM, de Silva MVC, Pathmeswaran A, Abeyewickreme W, Satoskar AR, Karunaweera ND. 2016. Pathogenesis of L.donovani induced cutaneous leishmaniasis: role of Tumor Necrosis Factor –alpha (TNF-α). Proceedings of the 25th Anniversary International Scientific Conference, Faculty of Medicine, University of Kelaniya. p 90 (Oral).
- Nuwani H Manamperi, Charisma S Fernando, Nishantha Pathirana Wimaladharma Abeyewickreme, Vipula C. de Silva, Nadira D. Karunaweera. 2015. Clinical and histopathological characteristics of cutaneous leishmaniasis in a group of military personnel in Sri Lanka. Proceedings of the 64th Annual Meeting of the American Society of tropical Medicine and Hygiene. Vol. 93 (4): p 336 (Poster).
- Manamperi NH, Fernando C, Pathirana KPN, Karunaweera ND, Abeyewickreme W, de Silva MVC. 2015. Histopathological spectrum in acute and chronic cutaneous leishmaniasis in Sri Lanka. Proceedings of the 128th Anniversary International Medical Congress of the Sri Lanka Medical Association. Abstract No. Pp 140.
Professional Contributions:
Positions held and holding in academic and scientific bodies :
- Sri Lanka College of Microbiologists – Member since 2014
- Sri Lanka Medical Association – Member since 2013
Positions held & holding in committees in the Faculty of Medicine & University of Kelaniya :
- 20th Anniversary Exhibition Committee, Faculty of Medicine (2011) – Member
- Library Committee - Member
Service Functions
- Teaching Undergraduate Medical students in the phase II Introductory module, Blood and Immunology module and Alimentary systems module
- OSPE coordinator – Second Examination for Medical Degrees, Unit 3 (2018 – to date)
- Supervision of Undergraduate research projects
- Diagnostic services for leishmaniasis
Ongoing Research
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Epidemiology and transmission of Leishmania donovani infections in Sri Lanka and Bhutan. Co-investigator (Clinical coordinator), funded by the National Institute of Health, USA.
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Interdisciplinary study of factors related to treatment outcome of Sri Lankan cutaneous leishmaniasis. Co-investigator, funded by the US-Japan Cooperative Medical Sciences program collaborative award.
Research Grants
- University Grants Commission of Sri Lanka (Grant No. UGC/VC/DRIC/PG/2013/KLN/03) to study “Host factors in the pathogenesis of cutaneous leishmaniasis due to Leishmania donovani in Sri Lanka”. May 2014 – March 2019.
- University of Kelaniya (Grant No. RP/03/04/06/01/2014) to study “Insitu cytokine expression profile and its role in the pathogenesis of cutaneous leishmaniasis due to Leishmania donovani”. September 2014 – March 2018.
Contact Details
Department
Parasitology
Parasitology
Tel
+94 11 2961290 Office)
+94 11 3065189 (Residence)
+94 77 2963344 (Mobile)
+94 11 2961290 Office)
+94 11 3065189 (Residence)
+94 77 2963344 (Mobile)
Email
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