Dr. J.W.N.Yasara
PhD in Molecular Medicine, MSc Biochemistry and Molecular Biology
Senior Lecturer (Contract basis)
Specialization
Hematology/Molecular Medicine
Research Interests
- Hematology
- Molecular Medicine
- Cancer Biology
Awards and fellowships
Academic honors :
- Senate honours for conducting high-quality research and publishing in the year 2022 in international indexed journal- University of Kelaniya Sri Lanka
- Senate honours for conducting high-quality research and publishing in the year 2021 in international indexed journal- University of Kelaniya Sri Lanka
- Senate honours for conducting high-quality research and publishing in the year 2020 in international indexed journal- University of Kelaniya Sri Lanka
- Best oral presentation for Anti-Oxidant and Anti-proliferative activity of Triphala at 10th International Research Conference at General Sir John Kotelawala Defense University
Publications
Book Chapters, Sections and Study Guides
- Yasara J.W.N and Mettananda S. Genetic modifiers of β-thalassemia and their therapeutic implications
Book title: Fetal Hemoglobin: The Panacea for Major β-Hemoglobinopathies Publisher: Nova Science Publishers, New York, USA (ISBN: 978-1-53617-955-2)
- Fejzo M , Rocha N , Cimino I , Lockhart S, Petry C, Kay R, Burling K, Barker P, George A, Yasara N et al., GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Nature (2023).
https://doi.org/10.1038/s41586-023-06921-9 - Badat M, Ejaz A, Hua P, Rice S, Zhang W, Hentges L, Fisher C, Denny N, Schwessinger R, Yasara N, Roy N, Issa F , Roy A, Telfer P , Hughes J, Mettananda S, Higgs D and Davies J
Direct correction of haemoglobin E/β- thalassaemia using base editors. Nature communication 19;14(1):2238
https://doi.org/10.1038/s41467-023-37604-8 - Karusheva Y, Petry CJ, Yasara N, Kottahachchi D, Premawardhena A, Barker P, Burling K, Sattar N, Welsh P, Mettananda S, O'Rahilly S
Association of GDF15 levels with body mass index and endocrine status in β‐thalassaemia. Clinical Endocrinology, 99: 182-189 (2023),
https://doi.org/10.1111/cen.14897 - Yasara N, Wickramarathne N, Mettananda C, Silva I, Hameed N, Attanayaka K, Rodrigo R, Wickramasinghe N, Perera L, Manamperi A, Premawardhena A, Mettananda S
A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion- dependent β-thalassaemia. Scientific Reports 12(1), 2752 (2022). https://doi.org/10.1038/s41598-022-06774-8 - Yasara N, Premawardhena A, Mettanand
A comprehensive review of hydroxyurea for β-haemoglobinopathies: the role revisited during COVID-19 pandemic Orphanet Journal of Rare Disease, 16(1), 114 (2021) https://doi.org/10.1186/s13023-021-01757-w - Yasara N, Wickramarathne N, Mettananda C, Manamperi A, Premawardhena A, Mettanand S. Efficacy and safety of oral hydroxyurea in transfusion dependent beta-thalassaemia: a protocol for randomized double-blind controlled clinical trial,BMJ open 2020 e041958
https://doi:10.1136/bmjopen-2020-041958 - Mettananda S, Yasara N, Fisher C.A, Taylor S, Gibbons R, Higgs D. Synergistic silencing of α-globin and induction of γ-globin by histone deacetylase inhibitor, vorinostat as a potential therapy for β-thalassaemia
Scientific Reports, 9(1), 11649 (2019)
https://doi:10.1038/s41598-019-48204-2 - Rathnasiri A, Rathnayaka H, Yasara N, Mettananda S Electronic screen device usage and screen time among preschool children in a suburban area of Sri Lanka, BMC pediatrics, 22(1),390(2022)
https://doi.org/10.1186/s12887-022-03452-6
- Niriella, M.A., Venkateswaran, S., Rajindrajith, S., Kodisinghe, K., De Silva, A.P., De Silva, H.J., Yasara, N., Mettananda, , Pelia, R.S., Gettler, K. and Cutler, D.J. Su1563: GWAS of inflammatory bowel disease in a Sri Lankan population revealed distinct and shared IBD allele architecture. Gastroenterology, 162(7), S-631.
- Yasara N, Wickramarathne N, Silva I, Hameed N, Attanayaka M.K.R, Jayasinghe V.L, Gunathilaka PACK, Wickramasinghe N, Rodrigo R, Perera L, Perera PS ,Mettananda KCD, Manamperi A, Premawardhena A, Mettananda S (2021). Hydroxyurea for transfusion dependent beta-thalassaemia: a randomized double-blind placebo-controlled clinical trial
134th anniversary international medical congress, Sri Lanka Medical Association (SLMA) - Yasara N, Premawardhena A, Perera P, Manamperi A and Mettananda S (2021) Efficacy of hydroxyurea in reducing the erythropoietic stress of ineffective erythropoiesis in transfusion dependent beta thalassaemia: a randomised, double-blind placebo-controlled clinical trial 77th annual sessions of Sri Lanka Association for the Advancement of Science
- Yasara N, Manamperi A and Mettananda S (2021) In vitro study to identify effects of fetal haemoglobin inducing agents on primary human erythroid 77th annual sessions of Sri Lanka Association for the Advancement of Science
- Yasara N, Manamperi A and Mettananda S (2021), In vitro study to identify effects of fetal haemoglobin inducing agents on primary human erythroid cells of beta-thalassaemia major 14th International Research Conference at General Sir John Kotelawala Defense University.
- Yasara N and Soysa P (2021). Lactate dehydrogenase (LDH) enzyme assay in cytotoxicity testing and interferences caused by Triphala 3rd Conference -College of Biochemists of Sri Lanka
- Rubasinghe D, Yasara N, Mettananda S (2021). Knowledge and practices on continuation of breast feeding and weaning among mothers of infants aged between 6 to 12 months in Kalutara district of Sri Lanka 134th anniversary international medical congress, Sri Lanka Medical Association (SLMA)
- Rathnasiri B.A.M, Rathnayaka H, Yasara N, Mettananda S (2021), use of electronic devices and screen time of pre-school children in homagama medical officer of health area. 133rd anniversary international medical congress, Sri Lanka Medical Association (SLMA)
- Yasara N, Wickramarathne N, Silva I, Hameed N, Attanayaka M.K.R, Jayasinghe V.L, Wickramasinghe N, Rodrigo R, Perera L, Mettananda KCD, Manamperi A, Premawardhena A, Mettananda S (2020). Efficacy and safety of oral hydroxyurea in patients with transfusion dependent β-thalassaemia: a randomized double-blind placebo-controlled clinical trial- 133rd anniversary international medical congress, Sri Lanka Medical Association (SLMA)
- Yasara W.N., Soysa P (2017). Anti-Oxidant and Anti-proliferative activity of Triphala 10th International Research Conference at General Sir John Kotelawala Defense University
- Yasara J.W.N., Soysa P (2018). Cytotoxicity and apoptosis inducing ability of Triphala Annual Research Symposium of Faculty of Medicine, University of Colombo
Pre-print publication
- Fejzo M , Rocha N , Cimino I , Lockhart S, Petry C, Kay R, Burling K, Barker P, George A, Yasara N et al., Fetally encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy [Preprint]. doi:10.1101/2023.06.02.542661.
Professional Contributions
Positions held and holding in academic and scientific bodies :
- Member of the Organization for Women in Science for the Developing World (OWSD) –
- Biological Society
- SLAAS
Medical Faculty Responsibilities
- Convener of the Foundation Module batch 36
Service Functions
- Teaching
- Supervision
- Research