As an academic research unit, the CTU has the advantage of having access to a large number of patients from multi-specialty tertiary care hospitals as well as the community, and to research knowledge and expertise available in other university departments. Coupled with the excellent project management skills that RemediumOne bring into the equation, we are in a unique position to design and conduct our own research as well as participate in large multi-centre clinical research programmes.
Recently concluded research
- VITAmins to Prevent Stroke (VITATOPS): a multi-centre, randomized, double-blind, placebo-controlled, clinical trial examining the efficacy and safety of multi-vitamin therapy in secondary stroke prevention.
The Lancet Neurology 2010; 9: 855-65 - Prevention of acute adverse reactions to antivenom following snakebite: a randomized, double-blind, placebo-controlled trial to assess efficacy and safety of pre-treatment with low-dose adrenaline, promethazine, and hydrocortisone, alone and in all possible combinations given immediately before infusion of antivenom to prevent acute reactions to antivenom.
PLoS Medicine 8(5): e1000435. doi:10.1371/journal.pmed.1000435 - CHInese Medicine Neuroaid efficacy
on stroke recovery
(CHIMES): a double-blind, placebo controlled, randomized, multicenter study to investigate the efficacy and safety of traditional Chinese medicine on stroke recovery.
International Journal of Stroke 2013;8(6): 491-4.
Cerebrovascular Disease 2013; 35(1): 18-22.
Stroke 2013; 44: 2093-2100.
Stroke 2013; 44: 3580-3
- Efficacy of nitric oxide in stroke (ENOS): a multi-centre, randomized, partial factorial design study on the management of high blood pressure in acute stroke.
Journal of Neurology Neurosurgery & Psychiatry 2013; 84(3): 342-7.
International Journal of Stroke 2014; 9(6): 711-20
Ongoing research
- Odyssey outcomes study: a randomized, double-blind, placebo-controlled, parallel-group study to evaluate the effect of SAR236553 on the occurrence of cardiovascular events in patients who have recently experienced an acute coronary syndrome event. This cardiovascular disease trial assesses the safety and efficacy of a novel lipid-lowering agent against the maximum tolerated doses of available statins to reduce mortality in patients who have experienced an acute coronary syndrome event.
http://www.odysseytrials.com/web/
- ASCOLT study: this double-blind, placebo-controlled, randomized clinical trial is the first prospective study to look at and evaluate the long term benefit of Aspirin in patients with Dukes C /high risk Dukes B colorectal cancer.
http://www.indox.org.uk/research/clinical/ascolt - COBRA-BPS: a cluster randomized clinical trial being conducted simultaneously in rural Bangladesh, Pakistan and Sri Lanka to assess efficacy of integrated primary care strategies to reduce high blood pressure. The study is funded by a joint programme research grant from the Medical Research Council (UK) / Wellcome Trust /DFID.