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RESEARCH GROUP
HEMOGLOBINOPATHIES,
HEREDITARY RED CELL DISORDERS AND IRON METABOLISM
RESEARCH ACTIVITIES CARRIED OUT
This group is carrying out clinical, epidemiological and translational research on haemoglobin disorders including β-thalassaemia, haemoglobin E β-thalassaemia, Sickle cell disease, α-thalassaemia, and hereditary red cell disorders like enzymopathies and membranopathies. The main emphasis is on the development of optimum tools for screening haemoglobin disorders in resource poor settings. With its close affiliation with the Paediatric, Adolescent and Adult Thalassaemia Units of the Colombo North Teaching Hospital, it has become a research hub for many international collaborators performing high-quality clinical and translational research on haemoglobinopathies.
GROUP MEMBERS
PUBLICATIONS
[Top 5 high-impact indexed papers]
- Premawardhena AP, Ediriweera DS, Sabouhanian A, Allen A, Rees D, de Silva S, Perera W, Katugaha N, Arambepola M, Yamashita RC, Mettananda S, Jiffry N, Mehta V, Cader R, Bandara D, St Pierre T, Muraca G, Fisher C, Kirubarajan A, Khan S, Allen S, Lamabadusuriya SP, Weatherall DJ, Olivieri NF. Survival and complications in patients with haemoglobin E thalassaemia in Sri Lanka: a prospective, longitudinal cohort study. Lancet Glob Health. 2022 Jan;10(1):e134-e141. doi: 10.1016/S2214- 109X(21)00446-0.
- Padeniya P, Ediriweera D, De Silva AP, Niriella M, Premawardhena A. The association between steatosis and liver damage in transfusion-dependent beta thalassaemia patients. Br J Haematol. 2022 Oct 4. doi: 10.1111/bjh.18492. Epub ahead of print. PMID: 36194160.
- Yasara N, Wickramarathne N, Mettananda C, Silva I, Hameed N, Attanayaka K, Rodrigo R, Wickramasinghe N, Perera L, Manamperi A, Premawardhena A, Mettananda S. A randomised double-blind placebo- controlled clinical trial of oral hydroxyurea for transfusion-dependent β- thalassaemia. Sci Rep. 2022 Feb 17;12(1):2752. doi: 10.1038/s41598-022- 06774-8. PMID: 35177777; PMCID: PMC8854735.
- Premawardhena A, Allen A, Piel F, Fisher C, Perera L, Rodrigo R, Goonathilaka G, Ramees L, Peto T, Olivieri N, Weatherall D. The evolutionary and clinical implications of the uneven distribution of the frequency of the inherited haemoglobin variants over short geographical distances. Br J Haematol. 2017 Feb;176(3):475-484. doi: 10.1111/bjh.14437. Epub 2016 Nov 29. PMID: 27897311.
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Premawardhana AP, Mudiyanse R, De Silva ST, Jiffry N, Nelumdeniya U, de Silva U, Lamabadusuriya SP, Pushpakumara K, Dissanayaka R, Jansz M, Rifaya I, Navarathne U, Thirukumaran V, Arambepola M, Dayanada Bandara W, Vaidyanatha U, Mendis D, Weerasekara K, De Silva N, Shantha Kumara DK, Amarasena SD, Hemantha KK, Refai MACM, Silva I, Hameed N, Rajiyah F, Mettananda S, Allen A, Weatherall DJ, Oliveri NF. A nationwide survey of hospital-based thalassemia patients and standards of care and a preliminary assessment of the national prevention program in Sri Lanka. PLoS One. 2019 Aug 16;14(8):e0220852. doi: 10.1371/journal.pone.0220852. PMID: 31419232; PMCID: PMC6697367.
Collaborators
International Collaborators and Institutions:
- Prof Douglas Higgs – University of Oxford, UK
- Prof. David Rees – Kings College Hospital London UK
- Prof. Nancy Olivieri – University of Toronto, Toronto, Canada
- Prof Stephen O'Rahilly – University of Cambridge, UK
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Prof James Davis – University of Oxford, UK
GRANT / FUNDING SUPPORT
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Global Challenges Research Fund Networking Grant – Academy of Medical Sciences,UK
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Investigator Driven Research Grant – National Research Council, Sri Lanka
CONTACT
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Faculty of Medicine,
University of Kelaniya,
P.O Box 6,
Thalagolla Road,
Ragama,
Sri Lanka
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